Generally, mosquito bites last between two hours and two days before the itching and swelling fades away. The range in time frame depends on several variables including what part of the body is bitten, how much saliva and anticoagulant is injected into the bite, and the fact that each person’s body has a different response to being bitten.
Mosquito bites to the extremities such as hands and feet will last longer than bites to the upper body because there is less blood flow to the extremities. When mosquito bites you, it injects certain anti-coagulant enzymes to prevent your blood from clotting, and also a mild anesthetic so that you will not detect being bitten. The bump on your skin from a mosquito bite is caused by an allergic reaction to these chemicals, and your circulatory system must clear them out to stop your body’s allergic reaction
To reduce the amount of time it takes the mosquito bite to go away, make sure you don’t scratch it because if you break the skin with your fingernails you are creating a new wound that is going to take longer to heal, and also leave your skin vulnerable to infection. You may rub the bite with your hand to reduce itching, which will also increase circulation to the area and reduce the time it takes for the bite to go away.
To reduce inflammation and itching on the bike, there are a few topical creams that you can apply directly to the skin. 1% hydro-cortisone cream is a steroid used to reduce inflammation and rashes and works well on mosquito bites, too. Calamine lotion also works well and can also be applied to reduce itching and inflammation.
So, the two keys to making your mosquito bites go away quickly are 1) don’t scratch them and break the skin, and 2) apply a topical cream your skin to reduce inflammation and itching.